M.Sc. 1st yr Med. Chemistry
Semester II, Credit-2
In this course students will understand the basic inorganic chemistry principles implemented by nature in controlling the overall functioning of biological system with emphasis on human beings. In short, it is study of inorganic chemistry in biological systems.
This course is for M.Sc. IInd yr students for all branches
1. General characteristics of hormones: chemistry, structure, synthesis, secretion, transport, metabolism & mechanism of action of hormones of the thyroid, hypothalamus, pituitary, pancreas, adrenals, glands, prostaglandins and gastro intestinal hormones, secondary messengers and their mode of action, calcium signaling, zinc fingers
2. Disorders related to hormones.
3. Cell membranes and intracellular receptors for hormones
4. Hormonal inter relationship
5. Biosynthesis of steroid hormones, cholera toxin, adenylate cyclase and TP, hormone overproduction and target cell insensitivity
6. EGF, NGF, PDGF, Enkephalin
Plant tissue culture
1. Media requirements: Sterilization and role of growth regulators, Requirements of aplant tissue culture laboratory,
2. PTC Techniques: Callus and cell suspension culture, Micropropogation, Conditioning of tissue culture plants (weaning and hardening),Somatic cell hybridization, Haploid (anther) culture, Embryo culture, Protoplast fusion, Somatic embryogenesis, Somaclonal variations, Cybrids and Allopheny, Agrobacterium mediated hairy root culture 3. Active principles in medicinal plants and phytochemistry of the metabolites of medicinal importance.
Animal tissue culture 1. Media requirements: preparation of medium and sterilization techniques, Advantages and disadvantages of natural and synthetic media 2. Cell culture methods: Hanging drop, suspension and monolayer culture, Behavior and characteristics of cells in culture, Primary and established cell lines, characteristics of transformed cells, Methods of cell preservation.
3. ATC techniques: Primary cultures and secondary cultures, cloning, heterocaryons, variant cells, contact inhibitions, Organ culture and cell and tissue banking
This course deals with biophysical techniques
This course deals with Metabolism of biomolecules, wherein a detailed metabolic pathways are discussed
Sound mathematical background and a good knowledge of quantum chemistry principles and chemical bonding is a prerequisite for this course. Following three topics are selected for this course.
1. Hartree Fock Theory
2. Semi-empirical Theories
M.Sc. Medicinal Chemistry
M.Sc. 2nd yer Analytical Chemistry
In this course students will learn about pharmacokinetic and pharmacodynamics of drug molecules
M.Sc. 2nd yr; Semester-IV; Credit-2
Excess or deficiency of essential metal ions can lead to many diseased conditions which can be treated by either replenishing those metal ions or removing them, if present in excess, using chelation therapy. Sometimes, metal complexes of non-essential, heavy metal ions like Pt, Tc, Bi, etc. play an important role in diagnosis, treatment and cure of some diseases. In this course, students will learn about how some metal-based drugs can modulate cellular responses while exerting their effect.
Practical for M.Sc. Part II Medicinal Chemistry